simplysheerene:

I refuse to let my current circumstances break my spirit.
I refuse to let my current circumstances break my spirit.
I refuse to let my current circumstances break my spirit.
I refuse to let my current circumstances break my spirit.
I refuse to let my current circumstances break my spirit.
I refuse to let my current circumstances break my spirit.
I refuse to let my current circumstances break my spirit.

13 hours ago with 32,105 notes — via nerdygirlchronicle, source simplysheerene
#daily reminder



swagitsune:

I’m bored.

13 hours ago with 3,338 notes — via oswinne, source swagitsune



futurefantastic:

game of thrones would kill off characters from other shows if they could

17 hours ago with 60,291 notes — via wohnjatsons, source futurefantastic



roobbstark:

I honestly saw this as a way of George telling D&D to fuck themselves

21 hours ago with 17,466 notes — via mrsweasley, source roobbstark
#faves



effyeahnerdfighters:

alysecampbell:

So I’m posting this a little bit late, but can we take a minute to appreciate the best graduation present ever? It’s an altered book that my mom made out of the Fault in Our Stars (since she knew it was one of my favorite books). It’s kind of like a scrapbook, only it’s made out of the pages of a book instead (John, I hope that you don’t mind that my mom altered it). She used pictures, clippings, material, and other things I’ve gotten way back from when I was little to Senior Year. She even made tabs in some places, so you can lift it up and see the quotes. Thank you so much mom. This truly is the best graduation present ever. 

Beautiful!

23 hours ago with 6,754 notes — via moroccanoverlord, source alysecampbell



spectacularuniverse:

I’ve seen this photograph very frequently on tumblr and Facebook, always with the simple caption, “Ghost Heart”. What exactly is a ghost heart?
More than 3,200 people are on the waiting list for a heart transplant in the United States. Some won’t survive the wait. Last year, 340 died before a new heart was found.The solution: Take a pig heart, soak it in an ingredient commonly found in shampoo and wash away the cells until you’re left with a protein scaffold that is to a heart what two-by-four framing is to a house.Then inject that ghost heart, as it’s called, with hundreds of millions of blood or bone-marrow stem cells from a person who needs a heart transplant, place it in a bioreactor – a box with artificial lungs and tubes that pump oxygen and blood into it - and wait as the ghost heart begins to mature into a new, beating human heart.Doris Taylor, director of regenerative medicine research at the Texas Heart Institute at St. Luke’s Episcopal Hospital in Houston, has been working on this – first using rat hearts, then pig hearts and human hearts – for years.The process is called decellularization and it is a tissue engineering technique designed to strip out the cells from a donor organ, leaving nothing but connective tissue that used to hold the cells in place. This scaffold of connective tissue – called a “ghost organ” for its pale and almost translucent appearance – can then be reseeded with a patient’s own cells, with the goal of regenerating an organ that can be transplanted into the patient without fear of tissue rejection.This ghost heart is ready to be injected with a transplant recipient’s stem cells so a new heart – one that won’t be rejected – can be grown.[source]

spectacularuniverse:

I’ve seen this photograph very frequently on tumblr and Facebook, always with the simple caption, “Ghost Heart”. What exactly is a ghost heart?

More than 3,200 people are on the waiting list for a heart transplant in the United States. Some won’t survive the wait. Last year, 340 died before a new heart was found.

The solution: Take a pig heart, soak it in an ingredient commonly found in shampoo and wash away the cells until you’re left with a protein scaffold that is to a heart what two-by-four framing is to a house.

Then inject that ghost heart, as it’s called, with hundreds of millions of blood or bone-marrow stem cells from a person who needs a heart transplant, place it in a bioreactor – a box with artificial lungs and tubes that pump oxygen and blood into it - and wait as the ghost heart begins to mature into a new, beating human heart.

Doris Taylor, director of regenerative medicine research at the Texas Heart Institute at St. Luke’s Episcopal Hospital in Houston, has been working on this – first using rat hearts, then pig hearts and human hearts – for years.

The process is called decellularization and it is a tissue engineering technique designed to strip out the cells from a donor organ, leaving nothing but connective tissue that used to hold the cells in place. 

This scaffold of connective tissue – called a “ghost organ” for its pale and almost translucent appearance – can then be reseeded with a patient’s own cells, with the goal of regenerating an organ that can be transplanted into the patient without fear of tissue rejection.

This ghost heart is ready to be injected with a transplant recipient’s stem cells so a new heart – one that won’t be rejected – can be grown.

[source]

23 hours ago with 174,528 notes — via spectacularuniverse
#cool



cleolinda:

coldfuckingsport:

kimlennox:

Scarlett’s stunt trainning for her role as Black Widow in Iron Man2

“Scarlett hadn’t really done an action role. And she assured me that she would work as hard as she needed to both get in sharp and do her stunts and learn all that stuff. She spent hours and hours and hours for months. By far the most dedicated actor when it came to stunt work and the physical work.” – Jon Favreau

and they have the gall to ask her about her diet

see, this is the kind of shit I want to hear about

23 hours ago with 99,179 notes — via multilateraldecisions, source kimlennox
#daily reminder



nic0tine-kisses:

I love this so much that it actually makes me feel a genuine sense of happiness

nic0tine-kisses:

I love this so much that it actually makes me feel a genuine sense of happiness

23 hours ago with 53,465 notes — via avengingpotatoangels, source nic0tine-kisses
#daily reminder



thorinoakenbutt:

castielandpie:

poryqon:

it bothers me that Kansas and Arkansas are not pronounced the same

I’m from the UK and I have been pronouncing Arkansas as Ar-Kansas my whole life

for all my non-american friends, Arkansas is pronounced ark-an-saw

23 hours ago with 135,034 notes — via th3-oncoming-storm, source poryqon
#useful



edismyfirefly:

notsomolly:

youcouldfuckingkissme:

accurate representation of menstruation

this is why chocolate is so effective

I think you broke Harry Potter

edismyfirefly:

notsomolly:

youcouldfuckingkissme:

accurate representation of menstruation

this is why chocolate is so effective

I think you broke Harry Potter

23 hours ago with 193,697 notes — via nopanickingatmydisco, source youcouldfuckingkissme